301 Effect of Maternal Supplementation of Saccharomyces Cerevisiae var. Boulardii During Late-Gestation and Lactation on Progeny Immune Status from Birth to 35 Days-of-age

Abstract The use of probiotics in swine production may be an alternative to antibiotics for both disease prevention and growth promotion. Limited data exist on their potential modulate offspring immune function when fed solely the dam. A study was designed assess immunomodulatory effect maternal supplementation Saccharomyces cerevisiae var. boulardii (scb) from gestational day 84 until end lactation (21-d period) status progeny short- long-term. total female piglets born 18 sows (n = 9/treatment) two boluses at 0600 h either CMCN-1079 (probiotic; PRO) or sugar (control; CON) were randomly selected farrowing 42/sow treatment). Blood samples taken birth (0), 1, 7, 14, 21 (weaning), 28, 35 days-of-age cortisol descriptive functional measures system progeny. Data analyzed using MIXED procedure SAS 9.4 with repeated measures. At birth, pigs CON-sows had greater (P< 0.001) plasma % lymphocytes, but PRO-sows neutrophils 0.001). Progeny a percent natural killer (NK) cytotoxicity 14 days-of-age, whereas concanavalin-A induced proliferation index days-of-age. Despite limited treatment x age effects, overall effects PRO C5a- IL-8 neutrophil chemotaxis than CON. Conversely, NK lipopolysaccharide-induced These imply that there are few long-term scb progeny, opportunity up